Novel biorelevant dissolution medium as a prognostic tool for polysaccharide-based colon-targeted drug delivery system (Only Abstract)

Abstract

To overcome the limitations of the conventionally used methods for evaluation of orally administered colon targeted delivery systems, a novel dissolution method using probiotics has been recently reported. In the present study, universal suitability of this medium composed of five different probiotics is established. Different delivery systems – mini tablets, liquisolid compacts, and microspheres coated with different polysaccharides – were prepared and subjected to sequential dissolution testing in medium with and without microbiota. The results obtained from fluid thioglycollate medium (FTM) based probiotic medium for all the polysaccharide based formulations showed statistically similar dissolution profile to that in the rat and goat cecal content media. Hence, it can be concluded that the developed FTM based probiotic medium, once established, may eliminate the need for further animal sacrifice in the dissolution testing of polysaccharide based colon targeted delivery system.